Modified mesenchymal stromal cells by in vitro transcribed mRNA: a therapeutic strategy for hepatocellular carcinoma.

María José CanteroBarbara BueloniLucrecia Gonzalez LlamazaresEsteban FioreLucia LameroliCatalina AtorrasagastiGuillermo MazzoliniMariana MalviciniJuan BayoMariana G Garcia

Published in: Stem cell research & therapy (2024)

Our results showed that IVT mRNA transfection is a suitable strategy for obtaining modified MSCs for therapeutic purposes. MSC/GM-CSF in combination with low doses of Dox led to a synergistic effect by increasing the proinflammatory tumour microenvironment, enhancing the antitumoural response in HCC.

Keyphrases

mesenchymal stem cells
stem cells
bone marrow
binding protein
umbilical cord
cerebrospinal fluid