Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles.
Vivian E SaperMichael J OmbrelloAdriana H TremouletGonzalo Montero-MartinSampath PrahaladScott W CannaChisato ShimizuGail DeutschSerena Y TanElaine F RemmersDimitri MonosTimothy HahnOmkar K PhadkeElaine CassidyIan FergusonVamsee MallajosyulaJianpeng XuJaime S Rosa DuqueGilbert T ChuaDebopam GhoshAnn Marie SzymanskiDanielle RubinJane C BurnsLu TianMarcelo A Fernandez-VinaElizabeth D MellinsJill A Hollenbachnull nullnull nullPublished in: Annals of the rheumatic diseases (2021)
DRESS-type reactions occur among patients treated with IL-1/IL-6 inhibitors and strongly associate with common HLA-DRB1*15 haplotypes. Consideration of preprescription HLA typing and vigilance for serious reactions to these drugs are warranted.
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