Large-Scale Identification of Lysine Crotonylation Reveals Its Potential Role in Oral Squamous Cell Carcinoma.

Xiteng Yin Hongbo ZhangZheng WeiYufeng WangShengwei HanMeng ZhouWenguang XuWei Han

Published in: Cancer management and research (2023)

Our study provides insights into the crotonylation modification of proteins in OSCC under hypoxic conditions and elucidates the associated biological processes and pathways. Crotonylation of HSP90AB1 in hypoxic conditions may enhance the glycolysis regulation ability in OSCC, offering novel perspectives on the regulatory mechanism of crotonylation in hypoxic OSCC and potential therapeutic targets for OSCC treatment.

Keyphrases

transcription factor
heat shock protein
heat shock
oxidative stress
risk assessment
combination therapy
human health
bioinformatics analysis