Hyperoside attenuates neuroinflammation, cognitive impairment and oxidative stress via suppressing TNF-α/NF-κB/caspase-3 signaling in type 2 diabetes rats.
Xiao ChenAdemola C FamurewaJian TangOladipupo Odunayo OlatundeOpeyemi Joshua OlatunjiPublished in: Nutritional neuroscience (2021)
The results suggested that hyperoside prevents DM-induced cognitive dysfunction, neuroinflammation and oxidative stress via antioxidant, anti-inflammatory and antiapoptotic mechanisms in rats.
Keyphrases
- oxidative stress
- cognitive impairment
- diabetic rats
- anti inflammatory
- induced apoptosis
- type diabetes
- lps induced
- signaling pathway
- dna damage
- ischemia reperfusion injury
- lipopolysaccharide induced
- traumatic brain injury
- glycemic control
- cell death
- rheumatoid arthritis
- inflammatory response
- high glucose
- cardiovascular disease
- adipose tissue
- cell proliferation
- endothelial cells
- metabolic syndrome
- nuclear factor
- heat shock protein