Endogenous Deoxyribonuclease Activity and Cell-Free Deoxyribonucleic Acid in Acute Ischemic Stroke: A Cohort Study.
Gerrit Maximilian GrosseNicole BlumeOmar Abu-FaresFriedrich GötzJohanna ErnstAndrei LeotescuMaria M GabrielTill van GemmerenHans WorthmannRalf LichtinghagenRabea ImkerChristine S FalkKarin WeißenbornRamona SchuppnerNicole de BuhrPublished in: Stroke (2022)
The interplay of endogenous deoxyribonuclease activity and cfDNA in acute stroke entails interesting novel diagnostic and potential therapeutic approaches. We confirm an independent association of cfDNA with a detrimental clinical course after stroke due to large vessel occlusion. This study provides first evidence for lower endogenous deoxyribonuclease activity as risk factor for SAI after severe stroke.
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