Photopheresis efficacy in the treatment of rheumatoid arthritis: a pre-clinical proof of concept.

Céline CoppardFrancis BonnefoyDalil HannaniFrançoise GabertOlivier ManchesJoel PlumasSylvain Perruche Laurence Chaperot

Published in: Journal of translational medicine (2019)

Our results demonstrate that ECP can control arthritis in CIA-mice, and clarifies ECP mechanisms of action, showing ECP efficacy and Th17 decrease only when arthritogenic T cells are contained within the treated sample. These data represent a pre-clinical proof of concept supporting the use of ECP in the treatment of RA in Human.

Keyphrases

rheumatoid arthritis
machine learning
electronic health record
combination therapy
adipose tissue
interstitial lung disease
skeletal muscle
replacement therapy
high fat diet induced
systemic sclerosis
insulin resistance
deep learning
artificial intelligence