Long-lasting persistence of large B-cell clones in hepatitis C virus-cured patients with complete response of mixed cryoglobulinaemia vasculitis.

Marcella VisentiniMartina Del PadreStefania ColantuonoBaoran YangYlenia Aura MinafòSilvia AntoniniMyriam CarnovaleAdriano De SantisAlessandro PulsoniGiuseppe Maria De SanctisLaura Gragnani Anna Linda Zignego Massimo Fiorilli Milvia Casato

Published in: Liver international : official journal of the International Association for the Study of the Liver (2019)

B-cell clones persist in MCV patients long after HCV infection has been cleared but halt the production of pathogenic antibody. These 'dormant' cells may be reactivated by events that perturb B-cell homeostasis and can give rise to the relapse of cryoglobulinaemic vasculitis.

Keyphrases

hepatitis c virus
end stage renal disease
human immunodeficiency virus
induced apoptosis
ejection fraction
chronic kidney disease
newly diagnosed
patient reported outcomes
oxidative stress
cell death
hiv infected
free survival
antiretroviral therapy