Risk of incident dementia following metformin initiation compared with noninitiation or delay of antidiabetic medication therapy.
Joanne SalasJohn E MorleyJeffrey F ScherrerJames S FloydSusan A FarrMax ZubatskyDouglas BartholdSascha DublinPublished in: Pharmacoepidemiology and drug safety (2020)
Results do not support initiating metformin earlier to prevent cognitive decline and, thus, may dampen enthusiasm for metformin as a potential antidementia drug. Randomized clinical trials could help clarify the relationship between metformin and cognitive decline.