Association of the Reduced Function Met420del Polymorphism of SLC22A1 with Metformin-Induced Gastrointestinal Intolerance in Ethiopian Patients with Type 2 Diabetes Mellitus.

Abraham DegagaSisay SirguHasniza Zaman HuriMaw Shin SimNavin Kumar Loganadan Tedla Kebede Birhanemeskel Tegene Ephrem Engidawork Workineh Shibeshi

Published in: Pharmacogenomics and personalized medicine (2024)

variants would be required to fully assess the effect of the gene on metformin induced gastrointestinal intolerance as several variants with a more severe loss of function have been described.

Keyphrases

copy number
high glucose
diabetic rats
end stage renal disease
drug induced
ejection fraction
prognostic factors
early onset
peritoneal dialysis
genome wide
oxidative stress
tyrosine kinase
endothelial cells
dna methylation
transcription factor
stress induced