Human fetal liver MSCs are more effective than adult bone marrow MSCs for their immunosuppressive, immunomodulatory, and Foxp3+ T reg induction capacity.

Yi YuAlejandra Vargas ValderramaZhongchao HanGeorges UzanSina NaserianEstelle Oberlin

Published in: Stem cell research & therapy (2021)

These results highlight the immunosuppressive activity of FL-MSCs on T cells and show for the first time that one of the main immunoregulatory mechanisms of FL-MSCs passes through active and functional T reg induction.

Keyphrases

mesenchymal stem cells
umbilical cord
bone marrow
endothelial cells
regulatory t cells
induced pluripotent stem cells
young adults