Substrate Availability of Mutant SPT Alters Neuronal Branching and Growth Cone Dynamics in Dorsal Root Ganglia.

Byung Kyu JunAnkush ChandraDika KuljisBrian P SchmidtFlorian S Eichler

Published in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)

Hereditary sensory neuropathy type 1 is an autosomal-dominant disorder that leads to a sensory neuropathy due to mutations in the serine palmitoyltransferase (SPT) enzyme. We investigated how mutant SPT and substrate levels regulate neurite growth. Because SPT is an important enzyme in the synthesis of sphingolipids, our data are of broader significance to other peripheral and metabolic disorders.

Keyphrases

spinal cord
wild type
electronic health record
neuropathic pain
spinal cord injury
structural basis
mass spectrometry
machine learning
high resolution
deep learning