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Identification and Characterization of a Small Molecule Bcl-2 Functional Converter.

Prasad R KopparapuMartin C PearceChristiane V LöhrCathy DuongHyo Sang JangShanthakumar TyavanagimattEdmond F O'DonnellHarikrishna NakshatriSiva K Kolluri
Published in: Cancer research communications (2024)
We report the identification of a small molecule that exposes the Bcl-2 killer conformation and induces death in Bcl-2-expressing cancer cells. Selective targeting of Bcl-2 and elimination of cancer cells expressing Bcl-2 opens up new therapeutic avenues.
Keyphrases
  • small molecule
  • protein protein
  • drug delivery