Cigarette smoking is a secondary cause of folliculin loss.

Xiuying LiYandong LaiZachary LaneHilary StrolloKazuya TanimuraJohn C SembratChunbin ZouMichael M MyerburgMauricio RojasSteven ShapiroYu JiangToru Nyunoya

Published in: Thorax (2022)

Our study demonstrates that CS exposure is a secondary cause of FLCN deficiency due to the enhanced proteolysis, which promoted airway epithelial cell death.

Keyphrases

cell death
cell proliferation
cell cycle arrest
replacement therapy
signaling pathway