Sphingosine-1-phosphate derived from PRP-Exos promotes angiogenesis in diabetic wound healing via the S1PR1/AKT/FN1 signalling pathway.

Tianyi Chen Peiyang SongMin HeShunli RuiXiaodong DuanYu MaDavid G ArmstrongWuquan Deng

Published in: Burns & trauma (2023)

PRP-Exos-S1P promotes angiogenesis in diabetic wound healing via the S1PR1/protein kinase B/FN1 signalling pathway. Our findings provide a preliminary theoretical foundation for the treatment of diabetic foot ulcers using PRP-Exos in the future.

Keyphrases

wound healing
platelet rich plasma
protein kinase
signaling pathway
cell proliferation
current status
vascular endothelial growth factor