Silica encapsulation of ZnO nanoparticles reduces their toxicity for cumulus cell-oocyte-complex expansion.

Antonella CamaioniMicol MassimianiValentina LacconiAndrea MagriniAntonietta SalustriGeorgios A SotiriouDilpreet SinghDimitrios BitounisBeatrice BoccaAnna PinoFlavia BaroneValentina ProtaIvo IavicoliManuel ScimecaElena BonannoFlemming R CasseePhilip DemokritouAntonio PietroiustiLuisa Campagnolo

Published in: Particle and fibre toxicology (2021)

Altogether, these results suggest that chemical composition, dissolution, and cell internalization are all responsible for the adverse effects of the tested NPs and support the importance of a tailored, safer-by-design production of NPs to reduce toxicity.

Keyphrases

single cell
cell therapy
oxide nanoparticles
stem cells
mesenchymal stem cells
room temperature
smoking cessation
ionic liquid