Technical development and validation of a clinically applicable microenvironment classifier as a biomarker of tumour hypoxia for soft tissue sarcoma.

Laura J ForkerBecky BibbyLingjian YangBrian LaneJoely IrlamHitesh B MistryMairah KhanHelen ValentineJames WyliePatrick ShenjereMichael LeahyPiers GauntLucinda BillinghamBeatrice M SeddonRob GrimerMartin RobinsonAnanya ChoudhuryCatharine M L West

Published in: British journal of cancer (2023)

This study comprehensively validates a microenvironment classifier befitting FFPE STS biopsies. Future uses include: (1) selecting high-risk patients for perioperative chemotherapy; and (2) biomarker-driven trials of hypoxia-targeted therapies.

Keyphrases

end stage renal disease
stem cells
ejection fraction
chronic kidney disease
endothelial cells
newly diagnosed
peritoneal dialysis
current status
locally advanced
patient reported