Potential of MALDI-TOF mass spectrometry to overcome the interference of hemoglobin variants on HbA1c measurement.

An-Ping XuWeijie XieYajun WangLing Ji

Published in: Clinical chemistry and laboratory medicine (2020)

In addition to conventional β-chain glycation, α-chain glycation can be used to calculate HbA1c values. The interference of Hb variants on HbA1c quantification can be overcome by employing the glycation of the globin chain without a genetic variant to estimate HbA1c values.

Keyphrases

mass spectrometry
copy number
liquid chromatography
gas chromatography
capillary electrophoresis
high performance liquid chromatography
high resolution
ms ms
dna methylation
gene expression
red blood cell