Antihypertensive medications and dementia in older adults with hypertension.
Suzanne G OrchardZhen ZhouMichelle FravelJoanne RyanRobyn L WoodsRory WolfeRaj C ShahAnne M MurrayAjay SoodChristopher M ReidMark Raymond NelsonLawrence J BeilinKevan R PolkinghorneNigel StocksMichael E ErnstPublished in: medRxiv : the preprint server for health sciences (2024)
Overall, AHM exposure in hypertensive older adults was not associated with decreased dementia risk, however, specific AHM classes were with risk direction determined by class; ARBs and β-blockers were superior to ACEIs and other classes in decreasing risk. Our findings emphasize the importance of considering effects beyond BP-lowering efficacy when choosing AHM in older adults.