Compared antioxidant activity among corticosteroids on cultured retinal pigment epithelial cells.

Nuzzi RaffaeleAlessandro MarcheseDario Ghigo

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2016)

Dexamethasone, besides suppressing intraocular inflammation, may protect human RPE cells from oxidative stress and decrease the oxidation rate of GSH. Triamcinolone and prednisolone, inducing GSH depletion, may contribute to reduce antioxidant capacity of ARPE-19 cells.

Keyphrases

oxidative stress
induced apoptosis
endothelial cells
signaling pathway
fluorescent probe
cell cycle arrest
dna damage
endoplasmic reticulum stress
diabetic rats
low dose
high dose
induced pluripotent stem cells
hydrogen peroxide
nitric oxide
heat shock
heat stress