Autoimmune Cytopenias Developing Late Post Alemtuzumab-Based Allogeneic Stem Cell Transplantation: Presentation of Short Case Series from a Transplant Center.
Rebecca LloydEmmanouil NikolousisBhuvan KishoreRichard LovellPaneesha ShankaraNervana Abou ZeidClaire HorganAlkistis Kyra PanteliadouGraham McIlroyEvgenia XenouMaria KaparouKathleen HolderVidhya MurthyAlexandros KanellopoulosPublished in: Cell transplantation (2021)
Stem cell transplantation remains the curative option for many patients with hematological malignancies. The long-term effects of these treatments on the patients and their immune systems have been extensively investigated, but there remains a paucity of data regarding autoimmune manifestations post-transplant, although these effects are well recognized.Herein we present the clinical picture and therapeutic approach in three patients (cases 1-3), with varied presentations of autoimmune disease post-transplant. Case 1 exhibited autoimmune hemolytic anemia and other autoimmune manifestations (serositis, thyroiditis), that were probably linked to graft versus relapsed leukemia effect. Cases 2 and 3 had pure red white cell aplasia and pure red cell aplasia, respectively, which were associated with hyperglobulinemia and a clonal T cell expansion.
Keyphrases
- stem cell transplantation
- end stage renal disease
- high dose
- multiple sclerosis
- chronic kidney disease
- ejection fraction
- newly diagnosed
- prognostic factors
- acute myeloid leukemia
- stem cells
- peritoneal dialysis
- mass spectrometry
- patient reported outcomes
- multidrug resistant
- diffuse large b cell lymphoma
- hodgkin lymphoma
- high speed
- artificial intelligence