γ-Terpinene complexed with β-cyclodextrin attenuates spinal neuroactivity in animals with cancer pain by Ca2+ channel block.
Lícia T S PinaThallita K RabeloGabriela G G TrindadeIggo K S AlmeidaMarlange A OliveiraPriscila L Dos SantosDiego Santos SouzaJosé E R de Menezes-FilhoCarla Maria Lins de VasconcelosSandra L SantosLuciana ScottiMarcus T ScottiAdriano A S AraújoJullyana S S QuintansLucindo J QuintansAdriana Gibara GuimarãesPublished in: The Journal of pharmacy and pharmacology (2022)
These results indicate that the complexation of γ-TPN into β-CD increases its stability and time effect, reducing spinal neuroactivity and inflammation by blocking calcium channels.