Au@Prussian Blue Hybrid Nanomaterial Synergy with a Chemotherapeutic Drug for Tumor Diagnosis and Chemodynamic Therapy.
Lifeng HangHailiang LiTao ZhangDandan MenCong ZhangPeng GaoQian-Ling ZhangPublished in: ACS applied materials & interfaces (2019)
Recently, the chemodynamic therapy (CDT) has been widely reported and applied to tumor therapy. However, only low level hydroxyl radicals (•OH) generated by the endogenous hydrogen peroxide alone are insufficient to kill the cancer cells. To overcome the insufficient therapeutic effect, this study reports a novel CDT based on Fenton catalyst Au@Prussian blue nanocubes (Au@PB NCs), subsequently encapsulated with doxorubicin (Dox). The in vitro and in vivo results indicate that the Dox-Au@PB NCs can take synergistic effects on tumor suppressor by CDT. In addition, Au@PB NCs possess high X-ray computed tomography contrast enhanced efficiency about ∼27.13 HU·mL·mg-1. This study highlights a great potential of the Dox-Au@PB NCs for tumor diagnosis and CDT.
Keyphrases
- hydrogen peroxide
- sensitive detection
- reduced graphene oxide
- computed tomography
- contrast enhanced
- heavy metals
- magnetic resonance imaging
- visible light
- magnetic resonance
- dual energy
- nitric oxide
- gold nanoparticles
- emergency department
- aqueous solution
- cancer therapy
- risk assessment
- ionic liquid
- diffusion weighted imaging
- positron emission tomography
- room temperature
- drug induced
- carbon dioxide