Genetic variation in CCR2 and CXCL12 genes impacts on CD4 restoration in patients initiating cART with advanced immunesupression.

Clara RestrepoMónica Gutierrez-RivasYolanda M PachecoMarcial GarcíaJulià BlancoLuz M MedranoMaría A Navarrete-MuñozFélix GutiérrezPilar MirallesDavid DalmauJuan Luis GómezMiguel GórgolasAlfonso CabelloSalvador Resino García José Miguel BenitoNorma Rallónnull null

Published in: PloS one (2019)

CCR2 rs1799864-AG or CXCL12 rs1801157-TT genotypes influence on the probability of poor CD4 recovery in the population of HIV patients starting cART with low CD4 counts. Genotyping of these polymorphisms could be used to estimate the risk of poor CD4 restoration, mainly in patients who are diagnosed late in the course of infection.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
gene expression
genome wide
transcription factor
regulatory t cells
genome wide identification