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Superior suppression of serum estrogens during neoadjuvant breast cancer treatment with letrozole compared to exemestane.

Bjørn-Erik BertelsenBjørg AlmåsKamilla FjermerosKristin VisteStephanie Beate GeislerTorill SauerKnut SelsåsJürgen Geisler
Published in: Breast cancer research and treatment (2024)
To the best of our knowledge, we present here for the first time a comprehensive and direct head-to-head, intra-patient-cross-over comparison of the aromatase inhibitor letrozole and the aromatase inactivator exemestane concerning their ability to suppress serum estrogen levels in vivo. All in all, our results clearly demonstrate that letrozole therapy results in a more profound suppression of serum E1 and E2 levels compared to exemestane.
Keyphrases
  • polycystic ovary syndrome
  • metastatic breast cancer
  • early breast cancer
  • healthcare
  • rectal cancer
  • lymph node
  • case report
  • stem cells
  • squamous cell carcinoma
  • adipose tissue
  • radiation therapy
  • clinical evaluation