MicroRNA-34a-Dependent Attenuation of Angiogenesis in Right Ventricular Failure.

Sushma ReddyDong-Qing HuMingming ZhaoShoko IchimuraElizabeth A BarnesDavid N CornfieldMiguel A Alejandre Alcazar Edda Spiekerkoetter Giovanni Fajardo Daniel Bernstein

Published in: Journal of the American Heart Association (2024)

In summary, miR-34a from fibroblasts, cardiomyocytes, and endothelial cells mediates capillary rarefaction by suppressing the hypoxia-inducible factor-1α-VEGF axis in RV hypertrophy/RVF, raising the potential for anti-miR-34a therapeutics in patients with at-risk RVs.

Keyphrases

endothelial cells
cell proliferation
long non coding rna
high glucose
vascular endothelial growth factor
long noncoding rna
mycobacterium tuberculosis
small molecule
extracellular matrix
human health
climate change