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Visible-Light-Induced Dual C(sp 3 )-H Bond Functionalization of Tertiary Amine via Hydrogen Transfer to Carbene and Subsequent Cycloaddition.

Kaixiu LuoYongqiang ZhaoZhiliang TangWeina LiJun LinYi Jin
Published in: Organic letters (2022)
Herein, we describe the dual C(sp 3 )-H bond functionalization of a tertiary amine through hydride-transfer-induced dehydrogenation, followed by cycloaddition, using an easily preparable diazoester as a new type hydride-acceptor precursor under mild, redox-neutral conditions. With carbene as a hydrogen acceptor, this method was demonstrated by the preparation of a broad range of functionalized isoxazoldines in moderate to good yields.
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