MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC.

Chenggong SunWenyu CaoChunping QiuChengcheng LiSamina DongolZhiwei ZhangRuifen DongKun SongXingsheng YangQing ZhangBeihua Kong

Published in: Journal of hematology & oncology (2020)

MiR-509-3 can sensitize ovarian cancer cells to Olaparib by impeding HR, which makes it a potential target in PARPi synergistic treatment. HR core gene analysis and RAD51 functional detection are prospectively feasible in prediction of PARPi response.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
dna damage
dna repair
copy number
genome wide
cancer therapy
risk assessment
human health
oxidative stress
transcription factor
genome wide identification