The leukotriene B 4 receptors BLT1 and BLT2 as potential therapeutic targets.
Takehiko YokomizoTakao ShimizuPublished in: Immunological reviews (2023)
Leukotriene B 4 (LTB 4 ) was recognized as an arachidonate-derived chemotactic factor for inflammatory cells and an important drug target even before the molecular identification of its receptors. We cloned the high- and low-affinity LTB 4 receptors, BLT1 and BLT2, respectively, and examined their functions by generating and studying gene-targeted mice. BLT1 is involved in the pathogenesis of various inflammatory and immune diseases, including asthma, psoriasis, contact dermatitis, allergic conjunctivitis, age-related macular degeneration, and immune complex-mediated glomerulonephritis. Meanwhile, BLT2 is a high-affinity receptor for 12-hydroxyheptadecatrienoic acid, which is involved in the maintenance of dermal and intestinal barrier function, and the acceleration of skin and corneal wound healing. Thus, BLT1 antagonists and BLT2 agonists are promising candidates in the treatment of inflammatory diseases.
Keyphrases
- wound healing
- oxidative stress
- induced apoptosis
- emergency department
- type diabetes
- cancer therapy
- gene expression
- metabolic syndrome
- mass spectrometry
- adipose tissue
- cell cycle arrest
- genome wide
- cystic fibrosis
- combination therapy
- transcription factor
- signaling pathway
- allergic rhinitis
- endoplasmic reticulum stress
- high fat diet induced
- replacement therapy
- pi k akt