Downstaging after preoperative chemoradiation for locally advanced rectal cancer is associated with better survival than pathologic stage 0-1 disease treated with upfront surgery.
Eli KasheriAvo ArtinyanKimberly OkaRuoyan ZhuNatalie SeiserMihran ShirinianMoshe BarnajianJason CohenJoshua EllenhornYosef NasseriPublished in: International journal of colorectal disease (2024)
Locally advanced rectal cancer downstaged after preoperative radiotherapy has significantly better survival compared to true pathologic stage 0-1 disease treated with upfront surgery. Response to chemoradiotherapy likely identifies a subset of patients with a particularly good prognosis.
Keyphrases
- locally advanced
- rectal cancer
- neoadjuvant chemotherapy
- minimally invasive
- phase ii study
- coronary artery bypass
- squamous cell carcinoma
- radiation therapy
- patients undergoing
- free survival
- surgical site infection
- genome wide
- clinical trial
- lymph node
- coronary artery disease
- dna methylation
- acute coronary syndrome
- percutaneous coronary intervention
- study protocol
- double blind