Association of MTHFR rs1801133 and homocysteine with Legg-Calvé-Perthes disease in Mexican patients.

José Guillermo Buendía-PazaránEdgar Hernández-ZamoraArmando O Rodríguez-OlivasLeonora Casas-ÁvilaMargarita Valdés-FloresElba Reyes-Maldonado

Published in: Orphanet journal of rare diseases (2022)

No association was found with the CBS, PT, COL1A1, and COL2A1 genes. Nevertheless, our results suggest a significant link between moderately elevated Hcy levels and the MTHFR C677T polymorphism in a cohort of Mexican children with LCPD.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
young adults
genome wide
prognostic factors
peritoneal dialysis
gene expression
patient reported outcomes
dna methylation
transcription factor
bioinformatics analysis