Proton-Pump Inhibitors to Prevent Gastrointestinal Bleeding - An Updated Meta-Analysis.

Ying WangSameer ParpiaLong GeDiane Heels-AnsdellHonghao LaiMeisam Abdar EsfahaniBei PanWaleed AlhazzaniStefan SchandelmaierFrancois LauzierYaseen ArabiJeffrey BarlettaAdam DeaneSimon FinferDavid WilliamsonSalmaan KanjiMorten H MøllerAnders PernerMette KragPaul J YoungJoanna C DionneNaomi HammondZhikang YeQuazi IbrahimDeborah Cook

Published in: NEJM evidence (2024)

High certainty evidence supports the association of proton-pump inhibitors with decreased upper gastrointestinal bleeding. Proton-pump inhibitors may have little or no effect on mortality, although a decrease in mortality in less severely ill patients and an increase in mortality in more severely ill patients remain possible. (PROSPERO number CRD42023461695.).

Keyphrases

end stage renal disease
systematic review
newly diagnosed
ejection fraction
prognostic factors
risk factors
patient reported