In vivo pH mapping with omega plot-based quantitative chemical exchange saturation transfer MRI.
Yang JiDongshuang LuPhillip Zhe SunIris Yuwen ZhouPublished in: Magnetic resonance in medicine (2022)
Our study determined the labile proton concentration and exchange rate underlying the in vivo APT MRI. The significant change in the exchange rate, but not the concentration of amide proton demonstrated that the pH effect dominates the APT contrast during tissue ischemia.