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Naive T cells inhibit the outgrowth of intractable antigen-activated memory T cells: implications for T-cell immunotherapy.

Sandhya SharmaMae WoodsNaren U MehtaTim SauerKathan S ParikhMichael Schmuck-HenneresseHuimin ZhangBirju MehtaMalcolm K BrennerHelen E HeslopCliona M Rooney
Published in: Journal for immunotherapy of cancer (2023)
Our findings suggest that naïve T cells inhibit the outgrowth of antigen-stimulated memory T cells, highlighting the profound effects of intra-T-cell subset interactions. Having overcome our inability to generate EBVSTs from many patients with lymphoma, we have introduced CD45RA depletion into three clinical trials: NCT01555892 and NCT04288726 using autologous and allogeneic EBVSTs to treat lymphoma and NCT04013802 using multivirus-specific T cells to treat viral infections after hematopoietic stem cell transplantation.
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