Effect of Kaempferol on Tacrolimus-Induced Nephrotoxicity and Calcineurin B1 Expression Level in Animal Model.

Ahmed Shaker Ali Abdullah Saddah AlmalkiBasma Tarek Alharthy

Published in: Journal of experimental pharmacology (2020)

Oxidative stress and calcineurin B1 are contributing factors in FK506-induced nephrotoxicity. Hence, inhibition of calcineurin enzyme is not limited to the immune cells. KMF could be a novel nephroprotective antioxidant.

Keyphrases

oxidative stress
diabetic rats
drug induced
high glucose
dna damage
induced apoptosis
endoplasmic reticulum stress
heat stress