Ethnicity-specific BRCA1, BRCA2, PALB2, and ATM pathogenic alleles in breast and ovarian cancer patients from the North Caucasus.
Anna P SokolenkoElvina Kh BakaevaAigul R VeninaEkatherina Sh KuliginaAleksandr A RomankoSvetlana N AleksakhinaYana V BelyshevaEvgeniya V BelogubovaIlya A StepanovOlga A ZaitsevaOlga S YatsukAlexandr V TogoZaur M KhamgokovAzinat O KadyrovaAlbert Sh PirmagomedovMarina B BolievaAlexandr A EpkhievAslan K TsutsaevMadina D ChakhievaKhalimat M KhabrievaIdris M KhabrievMirza A MurachuevBella N ButtaevaLiliya S BaboshkinaFatima I BayramkulovaIslam R KatchievLina Kh AlievaGrigory A RaskinSergey V OrlovZarema K KhachmamukKarine R LevonyanDariya M GichkoDmitriy V KirtbayaAlexey M DegtyariovLuisa V SultanovaHedi S MusayevaAlexey M BelyaevEvgeny N ImyanitovPublished in: Breast cancer research and treatment (2023)
This study adds to the evidence for the global-wide contribution of BRCA1/2 genes to HGSOC and BC morbidity, although the spectrum of their PVs is a subject of ethnicity-specific variations. The data on founder BRCA1/2 alleles may be considered when adjusting the BRCA1/2 testing procedure to the ethnic origin of patients.