TNFAIP3 Interacting Protein 3 Is an Activator of Hippo-YAP Signaling Protecting Against Hepatic Ischemia/Reperfusion Injury.

Junjie ZhouMan-Li HuMeiling HeXiaoming WangDating SunYongping HuangXu ChengJiajun FuJie CaiTengfei MaSong TianYufeng HuFengjiao HuDan LiuYanqi HeLanlan YanZhi-Gang SheXiao-Jing ZhangYan-Xiao JiHui LiuHongliang LiHailong YangPeng Zhang

Published in: Hepatology (Baltimore, Md.) (2021)

TNIP3 is a regulator of hepatic I/R injury that alleviates cell death and inflammation by assisting ubiquitination and degradation of LATS2 and the resultant YAP activation.TNIP3 represents a promising therapeutic target for hepatic I/R injury to improve the prognosis of liver surgery.

Keyphrases

cell death
ischemia reperfusion injury
oxidative stress
minimally invasive
coronary artery bypass
transcription factor
nuclear factor
immune response
acute coronary syndrome
amino acid
percutaneous coronary intervention