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Microwave-assisted organic synthesis of nucleoside ProTide analogues.

Cinzia BordoniCecilia Maria CimaElisa AzzaliGabriele CostantinoAndrea Brancale
Published in: RSC advances (2019)
A microwave enhanced synthesis of prodrug nucleotide (ProTide) analogues is presented. Comparison of conventional thermal heating reaction with microwave irradiation exemplifies the potential of the novel methodology herein presented for the selective 5'-phosphoramidate synthesis, without protection of the 3' position in the ribonucleoside.
Keyphrases
  • molecular docking
  • radiofrequency ablation
  • risk assessment
  • human health
  • clinical evaluation