Key Role of 12-Lipoxygenase and Its Metabolite 12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy.

Published in: Current eye research (2022)

12-LOX and its product 12-HETE take important part in DR pathogenesis and show their potential as future therapeutic targets for DR. Further studies are needed on the specific mechanism including 12-LOX pathway related molecules, 12-HETE receptors and downstream signaling pathways.

Keyphrases

diabetic retinopathy
editorial comment
optical coherence tomography
signaling pathway
current status
low density lipoprotein
pi k akt
case control
epithelial mesenchymal transition
human health
oxidative stress
risk assessment