Lacking Immunotherapy Biomarkers for Biliary Tract Cancer: A Comprehensive Systematic Literature Review and Meta-Analysis.

Giorgio FregaFernando P CossíoJesus M BanalesVincenzo CardinaleRocío I R Macías Chiara BraconiAngela Lamarca

Published in: Cells (2023)

From our analysis, PD-L1 expression was found to occur approximately in 26% of BTC patients, with minimal differences based on anatomical location. TMB-H and MSI molecular phenotypes occurred less frequently. We still lack a reliable biomarker, especially in patients with mismatch-proficient tumors, and we must need to make an effort to conceive new prospective biomarker discovery studies.

Keyphrases

papillary thyroid
small molecule
case report
squamous cell
high throughput
case control
lymph node metastasis
young adults