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Addition of low dose acetazolamide as an adjunct in patients undergoing high dose methotrexate is safe and beneficial.

Matthew KuAli BazarganConstantine Tam
Published in: Internal medicine journal (2021)
AZL appeared to diminish the incidence of HDMTx-induced toxicities, including reducing oedema-related weight gain. With mild, preventable hypokalaemia as the only noteworthy toxicity, AZL could be considered as an adjunct to HDMTx patient care.
Keyphrases
  • high dose
  • weight gain
  • low dose
  • patients undergoing
  • body mass index
  • birth weight
  • stem cell transplantation
  • high glucose
  • diabetic rats
  • risk factors
  • oxidative stress
  • drug induced
  • endothelial cells
  • physical activity