Deciphering the Efficacy of β-Lactams in the Face of Metallo-β-Lactamase-Derived Resistance in Enterobacterales: Supraphysiologic Zinc in the Broth Is the Culprit.

Kamilia AbdelraoufChristian M GillMatthew Gethers Giusy TiseoSimona BarniniMarco FalconeFrancesco MenichettiDavid P Nicolau

Published in: Open forum infectious diseases (2024)

Our data provide foundational support to establish pharmacokinetic/pharmacodynamic relationships using MICs derived in physiologic zinc concentration, which may better predict β-lactam therapy outcome.

Keyphrases

gram negative
escherichia coli
oxide nanoparticles
multidrug resistant
electronic health record
big data
klebsiella pneumoniae
bone marrow
cell therapy