The SARS-CoV-2 mutation landscape is shaped before replication starts.

Diego Masone Maria Soledad Alvarez Luis Mariano Polo

Published in: Genetics and molecular biology (2023)

Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated patients. Hence, we propose a model to explain where those mutations could originate during the replication cycle.

Keyphrases

sars cov
respiratory tract
end stage renal disease
respiratory syndrome coronavirus
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
gene expression
patient reported outcomes
genome wide