CB1 receptor-dependent desensitisation of TRPV1 channels contributes to the analgesic effect of dipyrone in sensitised primary sensory neurons.
Gilson Gonçalves Dos SantosRuihui LiMelissa Pui Een NgJulia Borges Paes LemesWillians Fernando VieiraIstvan NagyClaudia Herrera TambeliCarlos Amilcar ParadaPublished in: British journal of pharmacology (2020)
CB1 receptor-mediated inhibition of TRPV1 channels and TRPV1-mediated Ca2+ -influx- and CB1 receptor-dependent desensitisation of TRPV1 channels contribute to the anti-nociceptive effect of 4-AA in naive and inflamed conditions respectively. Agonists active at both CB1 receptors and TRPV1 channels might be useful as analgesics, particularly in inflammatory conditions.