Exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells facilitates diabetic wound healing by restoring keratinocyte autophagy.

Yan ShiShang Wang De-Wu LiuZhengguang WangYihan ZhuJun LiKui XuFurong LiHuicai WenRong-Hua Yang

Published in: Burns & trauma (2024)

Overall, the results of this study showed that hyBMSC-Exo-mediated transfer of miR-4645-5p inactivated MAPKAPK2-induced AKT-mTORC1 signaling in keratinocytes, which activated keratinocyte autophagy, proliferation and migration, resulting in diabetic wound healing in mice. Collectively, the findings could aid in the development of a novel therapeutic strategy for diabetic wounds.

Keyphrases

wound healing
signaling pathway
cell death
endoplasmic reticulum stress
oxidative stress
high glucose
cell proliferation
type diabetes
metabolic syndrome
endothelial cells
high fat diet induced
skeletal muscle