Computational modelling suggests that Barrett's oesophagus may be the precursor of all oesophageal adenocarcinomas.
Kit CurtiusJoel H RubensteinAmitabh ChakJohn M InadomiPublished in: Gut (2020)
There are likely few additional OAC cases arising in the US population outside those expected from individuals with BE. Effective screening of high-risk patients could capture the majority of population destined for OAC progression and potentially decrease mortality through early detection and curative removal of small (pre)cancers during surveillance.