Lercanidipine ameliorated doxorubicin-induced neuroinflammation and maintained the expressions of choline acetyltransferase via enhancing the levels of PI3K/AKT/HIF1-α expressions.
Melike D UnluSanem AsciHalil AsciSerife TasanOzlem OzmenRumeysa TanerSerpil DemirciPublished in: Molecular biology reports (2024)
Both LRD doses reversed all these findings, but LRD2 was observed to be more effective. In conclusion, we determined that LRD has potential therapeutic effect by reducing DOX-induced neuroinflammation, oxidative stress and apoptosis in brain tissues.
Keyphrases
- oxidative stress
- pi k akt
- diabetic rats
- cell cycle arrest
- signaling pathway
- high glucose
- traumatic brain injury
- cell proliferation
- lipopolysaccharide induced
- gene expression
- cell death
- drug induced
- cognitive impairment
- endothelial cells
- endoplasmic reticulum stress
- dna damage
- drug delivery
- induced apoptosis
- resting state
- multiple sclerosis
- cancer therapy
- climate change
- inflammatory response
- functional connectivity