Antimicrobial O-Alkyl Derivatives of Naringenin and Their Oximes Against Multidrug-Resistant Bacteria.
Anna Duda-MadejJoanna KozłowskaPaweł KrzyżekMirosław AniołAlicja SeniukKatarzyna JermakowEwa DworniczekPublished in: Molecules (Basel, Switzerland) (2020)
New antimicrobial agents are needed to address infections caused by multidrug-resistant bacteria. Here, we are reporting novel O-alkyl derivatives of naringenin and their oximes, including novel compounds with a naringenin core and O-hexyl chains, showing activity against clinical strains of clarithromycin-resistant Helicobacter pylori, vancomycin-resistant Enterococcus faecalis, methicillin-resistant Staphylococcus aureus, and beta-lactam-resistant Acinetobacter baumannii and Klebsiella pneumoniae. The minimum inhibitory concentrations (MICs), which provide a quantitative measure of antimicrobial activity, were in the low microgram range for the selected compounds. Checkerboard assays for the most active compounds in combination with antibiotics revealed interactions that varied from synergistic to neutral.
Keyphrases
- multidrug resistant
- helicobacter pylori
- acinetobacter baumannii
- klebsiella pneumoniae
- methicillin resistant staphylococcus aureus
- gram negative
- drug resistant
- staphylococcus aureus
- helicobacter pylori infection
- ionic liquid
- escherichia coli
- high throughput
- pseudomonas aeruginosa
- high resolution
- single cell
- emergency department
- mass spectrometry
- adverse drug
- structure activity relationship
- cancer therapy