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Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.

Jiao FengWeiqi DaiYuqing MaoLiwei WuJingjing LiKan ChenQiang YuRui KongSainan LiJie ZhangJie JiJianye WuWenhui MoXuanfu XuChuan-Yong Guo
Published in: Journal of experimental & clinical cancer research : CR (2020)
Simvastatin can inhibit the HIF-1α/PPAR-γ/PKM2 axis, by suppressing PKM2-mediated glycolysis, resulting in decreased proliferation and increased apoptosis in HCC cells, and re-sensitizing HCC cells to Sora.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • endoplasmic reticulum stress
  • signaling pathway
  • oxidative stress
  • cell death
  • pi k akt
  • insulin resistance
  • endothelial cells
  • type diabetes
  • skeletal muscle