Total Synthesis of the Sesquiterpene (-)-Merrillianin.
Isamu ShiinaTakashi IizumiSaori TaniguchiMasuhiro SugimotoTakahisa ShimazakiYu-Suke YamaiGo OgawaTetsuro YamadaShojiro ShinoharaYosuke KageyamaTeppei KubokiYuki SuwaKeita YonekuraKeiichi ItoKiyotaka ToyoyamaSatoru TateyamaTakahiro MoriTakatsugu MurataPublished in: Organic letters (2023)
The first total synthesis of (-)-merrillianin ( 1 ), which is a natural sesquiterpene with a tricyclic structure having a cyclopentane ring and five- and seven-membered lactone parts, is demonstrated. This asymmetric total synthesis enabled the absolute stereostructure determination of naturally occurring (-)- 1 .