Pathologic complete response following low-dose radiation for advanced oral cavity cancer in a patient with human immunodeficiency virus.
Amy B LemingAndrea L JohnstonGreg A KremplEvan J FowleDaniel J MortonChristina E HensonPublished in: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale (2022)
To our knowledge, this is the first case of pathologic complete response for a patient on HAART following a single cycle of the Quad-Shot regimen for advanced oral cavity SCCa. Protease inhibitors in HAART can induce spontaneous tumor regression via inhibition of proteasome function and activation of apoptosis, and thus act as a cancer therapeutic.
Keyphrases
- human immunodeficiency virus
- papillary thyroid
- low dose
- hepatitis c virus
- antiretroviral therapy
- case report
- neoadjuvant chemotherapy
- squamous cell
- hiv infected patients
- healthcare
- hiv infected
- oxidative stress
- endoplasmic reticulum stress
- squamous cell carcinoma
- high dose
- hiv aids
- hiv positive
- cell cycle arrest
- signaling pathway